![]() It may be over adaptation of their immune response, side effects of the natural immune response, lingering effects of the virus or combinations thereof,” Dr. “We don’t know exactly why some suffer from long-term symptoms. One thought is that remnants of the virus still elicit an immune response from the body, causing persistent symptoms. Other hypotheses include an exaggerated immune response to the initial infection or an autoimmune phenomenon. “Loss of smell may be most common and longest-lasting, but brain fog, fatigue, body or muscle aches, headaches and shortness of breath are not infrequent.” What causes the lingering symptoms?Įxperts aren’t sure why some suffer long-term symptoms and others don’t. “Up to half or slightly more patients with symptomatic COVID-19 can have lingering symptoms for weeks or months after initial infection, of varying degrees,” said Mark Meeker, DO, an internal medicine physician and vice president of Community Medicine for OSF HealthCare. However, reducing or eliminating virus persistence can be an added benefit to getting the COVID-19 vaccine. The vaccine is not going to remove scarring or reverse permanent damage. Some COVID-19 issues like heart and lung damage can be permanent or indicate virus persistence. While the lingering symptoms of COVID-19 are usually minor, they can disrupt your life in some cases. While there are no official studies, long-haulers seem to find some relief after getting the COVID-19 vaccine. As a result, these people are called long-haulers. doi: 10.3390/neurolint13040061.Many people with COVID-19 have experienced lingering symptoms after recovering from the virus. Spectrum of Neuroimaging Findings in Post-COVID-19 Vaccination: A Case Series and Review of Literature. ![]() Sriwastava S., Shrestha A.K., Khalid S.H., Colantonio M.A., Nwafor D., Srivastava S. Spectrum of neurological complications following COVID-19 vaccination. Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination. Pozzetto B., Legros V., Djebali S., Barateau V., Guibert N., Villard M., Peyrot L., Allatif O., Fassier J.-B., Massardier-Pilonchéry A., et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T-cell responses. Sahin U., Muik A., Derhovanessian E., Vogler I., Kranz L.M., Vormehr M., Baum A., Pascal K., Quandt J., Maurus D., et al. Ritchie H.E., Mathieu L., Rodés-Guirao C., Appel C., Giattino E., Ortiz-Ospina J., Hasell B., Macdonald D., Roser B.a.M. Further studies with non-vaccinated controls might help in understanding the pathophysiologic mechanisms of these neurological manifestations following COVID-19 vaccination.ĬOVID-19 vaccination GBS Janssen/Johnson and Johnson and AstraZeneca vaccine Moderna Pfizer BioNTech transverse myelitis. High vigilance with early identification and treatment leads to better outcomes. Several CNS and PNS adverse events have occurred post-COVID-19 vaccination, including CVST, GBS, and TM. However, most cases overall (42 out of 51) were non-fatal (82%). Nine (64%) out of the 14 patients with CVST died. Most occurred with the AstraZeneca (28.55%), Pfizer-BioNTech (9.18%), and Moderna (8.16%) vaccines. The most common PNS manifestation was GBS (14.67%) found in males (71%) older than 50 years (79%), followed by Bell's palsy (5.24%) and others (2.10%). Others included CNS demyelinating disorders (TM, ADEM, MS, NMOSD) (9.30%), encephalopathy/encephalitis (3.10%), and others (4.13%). The most common CNS manifestation was CVST (14.47%), found in females (64%) younger than 50 years (71%) after the first AstraZeneca dose (93%). The literature search and data analysis were performed by two independent reviewers according to prespecified inclusion and exclusion criteria using PRISMA. We conducted a thorough literature search of Google Scholar and PubMed from 1 December 2020 until 10 October 2021 and included all the case studies of COVID-19 vaccine-associated neurological side effects. Through this systematic review, we aim to discern these CNS and PNS manifestations following the COVID-19 vaccine to help produce methods to mitigate them. ![]() With 10 vaccines approved by the WHO and nearly 48% of people fully vaccinated worldwide, we have observed several individual case studies of neurological manifestations post-COVID-19 vaccination.
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